Callie Andrews has looked forward this semester but Lexi is still after her, boyfriend Clint wants her back but Gregory has decided to fight for her, Vanessa still has not forgiven her, and working on the Harvard Crimson is taking a toll, causing Callie to yearn for spring break.

Sent by her parents to find food, Mahalia Mouse finds herself trapped in a backpack and transported to a physics classroom at Harvard University, where she discovers an aptitude for science.